In the 14th Century, the harmony among humans, animals, and gods started to crumble. Infected by an animal attack, the protagonist, young Ashitaka, seeks a cure from the deer-like god Shishigami. During his journey, he witnesses humans ravaging the Earth, angering the wolf god Moro and Princess Mononoke, his human companion. Ashitaka’s efforts to mediate peace among them resulted in conflict.